HSLS Update

Proteome Bioknowledge Library

Proteome Bioknowledge Library is a suite of six protein-centric databases containing information on more than 75,000 human, mouse, rat, worm, yeast and other proteins useful to life sciences research. A search and data analysis tool, Bioknowledge® Retriever, makes it possible to search these databases by gene symbols or other properties associated with proteins of interest, or in batch using GenBank® and LocusLink accession numbers.

Proteome Bioknowledge Library databases include:

• HumanPSDTM : (human, rat and mouse).
• GPCR-PDTM : G coupled-protein receptors and downstream signaling proteins for human, mouse & rat.
• YPD TM : Saccharomyces cerevisiae
• PombePDTM : Schizosaccharomyces pombe
• MycoPathPDTM : Fungal pathogen database containing 17 fungal pathogens.
• WormPDTM : Caenorhabditis elegans

The databases and their links are color-coded, and extensive user documentation is available. You can:

• Use Bioknowledge Retriever to search by gene symbols, keywords, properties or sequence.
• Use ‘Quick Search’ to find specific protein using a gene symbol or keyword.
• Search by ‘Properties Search’ using criteria such as Gene Ontology terms, Pfam domains, expression or disease.
• Use ‘Sequence Search’ to find proteins using BLAST or peptide search form.
• Retrieve annotations for your list of proteins. Data output lists proteins with gene symbols, and provide links to associated protein reports and property trees.
• Search mouse mutant phenotypes by viability, disease model and anatomical or physiological phenotype.

This resource is available from the HSLS molecular biology and genetics resources portal, under ‘Guides’ <www.hsls.pitt.edu/guides/genetics> or directly via <www.incyte.com/control/tools/proteome>. First-time users must register to establish a personal account and password. Access is currently restricted to the University of Pittsburgh, Oakland campus users.

--Sugandha Sharma