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URL:
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http://www.mitop.de/
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What you can do:
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Search for comprehensive genetic and functional information on both nuclear- and mitochondrial-encoded mitochondrial proteins and their genes in human, mouse, yeast and other model organisms.
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Highlights:
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- MITOP contributes to the systematic genetic characterization of the mitochondrial proteome in relation to human disease
- The five species files--Saccharomyces cerevisiae, Mus musculus, Caenorhabditis elegans, Neurospora crassa and Homo sapiens--include annotated data derived from a variety of online resources and the literature.
- A wide spectrum of search facilities is given in the overlapping sections 'Gene catalogues', 'Protein catalogues', 'Homologies', 'Pathways and metabolism' and 'Human disease catalogue' including extensive references and hyperlinks to other databases.
- Central features are the results of various homology searches, which should facilitate the investigations into interspecies relationships.
- The 'Human disease catalogue' contains tables with a total of 110 human diseases related to mitochondrial protein abnormalities, sorted by clinical criteria and age of onset.
- MitoP2 enables (i) the identification of putative orthologous proteins between these species to study evolutionarily conserved functions and pathways; (ii) the integration of data from systematic genome-wide studies such as proteomics and deletion phenotype screening; (iii) the prediction of novel mitochondrial proteins using data integration and the assignment of evidence scores; and (iv) systematic searches that aim to find the genes that underlie common and rare mitochondrial diseases.
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Keywords:
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- mitochondrial protein abnormalities
- mitochondrial diseases
- mitochondrial dysfunctions
- mitochondrial proteome
- mitochondrial proteins
- mitochondrial protein prediction
- mitochondrial targeting sequences
- human disease genes
- mitochondrial protein evolution
- pathway evolution
- mitochondria
- signalling sequences
- mitochondrial proteome mapping
- mitochondrial protein-protein interactions
- mitochondrial expression profile
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Literature and Tutorials:
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PubMed Link: MITOP -- database for mitochondria-related proteins, genes and diseases
PubMed Link of 2006 update: MitoP2: the mitochondrial proteome database--now including mouse data
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This record last updated: 02-21-2006
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