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URL:
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http://www.ncbi.nlm.nih.gov/Structure/cdd/cdd.shtml
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What you can do:
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Identify conserved domain in a protein sequence.
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Highlights:
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- CDD is a collection of multiple sequence alignments and derived database search models, which represent protein domains conserved in molecular evolution.
- The collection is part of NCBI's Entrez query and retrieval system.
- CDD provides annotation of domain footprints and conserved functional sites on protein sequences.
- Precalculated domain annotation can be retrieved for protein sequences tracked in NCBI's Entrez system, and CDD's collection of models can be queried with novel protein sequences via the CD-Search service at http://www.ncbi.nlm.nih.gov/Structure/cdd/wrpsb.cgi.
- Starting with the latest version of CDD, v2.14, information from redundant and homologous domain models is summarized at a superfamily level, and domain annotation on proteins is flagged as either 'specific' (identifying molecular function with high confidence) or as 'non-specific' (identifying superfamily membership only).
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Keywords:
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- conserved domains
- protein domain alignments
- protein domains
- protein motifs
- protein families
- proteins structures
- domain architecture
- protein annotation tool
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Literature and Tutorials:
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PubMed Link: CDD
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2005 update: 2005 update of CDD
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2007 Update: CDD: a conserved domain database for interactive domain family analysis
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2009 Update: CDD: specific functional annotation with the Conserved Domain Database
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