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URL:
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http://srs6.bionet.nsc.ru/srs6bin/cgi-bin/wgetz?-page+LibInfo+-newId+-lib+ASPD_ALIGN
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What you can do:
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Search for information on full-length proteins, protein domains and peptides that were obtained through in vitro directed evolution processes.
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Highlights:
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- The ASPD database contains data on 195 selection experiments, which were described in 112 original papers (as of 2004).
- For each experiment, information on following subjects is given: the target for binding; the protein or peptide which serves as the template for library construction and the native protein which binds the target; aligned sequences of proteins or peptides retrieved through in vitro evolution and relevant native or constructed sequences; the number of rounds of selection/amplification; and the number of occurrences of clones with each sequence.
- It allows for simple queries using the names and keywords. It is also possible to use complex queries by means of the SRS system.
- There is a BLAST search tool against the ASPD for looking directly for homologous sequences.
- Research tools of the ASPD allow the analysis of pairwise correlations in the sequences of proteins and peptides selected against one target.
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Keywords:
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- in vitro evolution
- artificially selected proteins
- artificially selected peptides
- phage display
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Literature and Tutorials:
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PubMed Link: ASPD
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