|
URL:
|
http://bioinf.xmu.edu.cn/software/cytosvm/cytosvm.php
|
|
What you can do:
|
An advanced server for identification of cytokine-receptor interactions.
|
|
Highlights:
|
- To discover novel cytokine-receptor interactions, an advanced support vector machines (SVMs) model, CytoSVM, was constructed.
- This model was iteratively trained using 449 mammal (except rat) cytokine-receptor interactions and about 1 million virtually generated positive and negative vectors in an enriched way.
- Final independent evaluation by rat's data received sensitivity of 97.4%, specificity of 99.2% and the Matthews correlation coefficient (MCC) of 0.89.
- A web-based server was created to accept primary protein sequence and present its probabilities to interact with one or several cytokines.
- Moreover, this model was applied to identify putative cytokine-receptor pairs in the whole genomes of human and mouse.
- Excluding currently known cytokine-receptor interactions, total 1609 novel cytokine-receptor pairs were discovered from human genome with probability approximately 80% after further transmembrane analysis.
- These cover 220 novel receptors (excluding their isoforms) for 126 human cytokines.
|
|
Keywords:
|
- cytokine
- cytokines
- dipeptides
- cytokine receptor interactions
- cytokine-receptor
|
|
Literature and Tutorials:
|
PubMed Link: CytoSVM: an advanced server for identification of cytokine-receptor interactions
|
This record last updated: 06-02-2008
|
