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URL:
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http://hhsenser.tuebingen.mpg.de/
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What you can do:
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Conduct exhaustive intermediate profile searches of a set of homologous protein sequences.
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Highlights:
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- HHsenser is the first server to offer exhaustive intermediate profile searches, by combining with pairwise comparison of hidden Markov models.
- Starting from a single protein sequence or a multiple alignment, it can iteratively explore whole superfamilies, producing few or no false positives.
- The output is a multiple alignment of all detected homologs.
- It may also aid applications that rely on diverse multiple sequence alignments as input, such as homology-based structure and function prediction, or the determination of functional residues by conservation scoring and functional subtyping.
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Keywords:
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- protein sequence analysis tool
- protein profile search tool
- protein motif detection tool
- protein homologous sequence analysis tool
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Literature and Tutorials:
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PubMed Link: HHsenser -- exhaustive transitive profile search using HMM–HMM comparison
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