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URL:
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http://bioinformatics.bmc.uu.se/evaller.html
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What you can do:
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Predict allergenicity of a protein sequence.
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Highlights:
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- EVALLER TM accepts a single amino acid sequence in FASTA format, which should either be pasted into the acceptor window or uploaded as a file. The output includes a two-category assignment (presumptive allergen or presumptive non-allergen) as well as a scoring value and a ratio number. These numbers, and particularly the latter one, are provided to inform on the degree of assessment certainty for a DFLAP score value. The posterior probability ratio, directly derived from the DFLAP score value, expresses a confidence-related figure, i.e. an index of categorisation firmness. Phrased in greater detail, the ratio involves computation of the probability for being either allergen or non-allergen based on output of a set (1175 entities) of training amino acid sequences that were fed to EVALLER TM. Due to differences in distribution profiles of these two categories the maximal ratio for non-allergens is 150, whereas those of allergens rapidly escalate to very higher numbers. Moreover, the algorithm will inappropriately assign a gradually lower ratio to non-allergens with unusually low score values. Therefore, the EVALLER TM output on ratios will rise to limits, beyond which 150 (max) and >1000, respectively, are displayed.
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Keywords:
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- immunology
- antigenicity
- antibody
- Cross Reactions
- allergen-related motifs,
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Literature and Tutorials:
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PubMed Link: EVALLER: a web server for in silico assessment of potential protein allergenicity.
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This record last updated: 10-22-2007
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