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URL:
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http://cast.engr.uic.edu
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What you can do:
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Identify and measure surface accessible pockets as well as interior inaccessible cavities, for proteins and other molecules.
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Highlights:
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- This web server provides an online resource for locating, delineating and measuring concave surface regions on three-dimensional structures of proteins.
- These include pockets located on protein surfaces and voids buried in the interior of proteins.
- The measurement includes the area and volume of pocket or void by solvent accessible surface model (Richards' surface) and by molecular surface model (Connolly's surface), all calculated analytically.
- CASTp can be used to study surface features and functional regions of proteins.
- CASTp includes a graphical user interface, flexible interactive visualization, as well as on-the-fly calculation for user uploaded structures.
- The 2006 version of CASTp includes annotated functional information of specific residues on the protein structure.
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Keywords:
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- protein topology
- protein topology analysis tool
- protein surface regions
- protein surface region measurement tool
- protein structure analysis tool
- protein active site prediction tool
- protein functional site analysis tool
- protein binding site analysis tool
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Literature and Tutorials:
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PubMed Link: CASTp -- Computed Atlas of Surface Topography of proteins
PubMed Link of 2006 Update: CASTp: computed atlas of surface topography of proteins with structural and topographical mapping of functionally annotated residues
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