In patients with septic thrombophlebitis what are the indications for surgical management?

April 29th, 2008

Intravenous heparin in combination with antibiotics for the treatment of deep vein septic thrombophlebitis: a systematic review. Eur J Pharmacol. 2007 Feb 28;557(2-3):93-8.

Surgical treatment of septic deep venous thrombosis. Surgery. 1995 Jul;118(1):49-53.

In patients with suspected neoplastic myopathy what are the labs?

April 29th, 2008

Laboratory testing in the diagnosis and management of idiopathic inflammatory myopathies. Rheum Dis Clin North Am. 2002 Nov;28(4):859-90, viii.

How sensitive is CT scan for picking up ischemic colitis?

April 29th, 2008

Ischemic colitis: CT evaluation of 54 cases. Radiology. 1999 May;211(2):381-8.

Case of the month. Ischemic colitis. Crit Rev Comput Tomogr. 2002;43(6):395-7.

In patients with interstitial lung disease what is the role of lung biopsy in diagnosis?

April 29th, 2008

Surgical biopsy: its appropriateness in diagnosing interstitial lung disease. Curr Opin Pulm Med. 2006 Sep;12(5):331-6.

Diagnosis of interstitial lung diseases. Mayo Clin Proc. 2007 Aug;82(8):976-86.

Challenges in pulmonary fibrosis. 1: Use of high resolution CT scanning of the lung for the evaluation of patients with idiopathic interstitial pneumonias. Thorax. 2007 Jun;62(6):546-53.

In patients with MGUS what are the indications for doing a bone marrow biopsy?

April 29th, 2008

Should bone marrow examination be routinely performed for the diagnosis of monoclonal gammopathy of undetermined significance? Isr Med Assoc J. 2006 Dec;8(12):840-2.

Monoclonal gammopathy of undetermined significance and smoldering multiple myeloma. Hematol Oncol Clin North Am. 2007 Dec;21(6):1093-113, ix.

In patients immunosuppressed with 6-mercaptopurine, what is the incidence/risk of developing lymphoma?

April 29th, 2008

Increased risk of lymphoma among inflammatory bowel disease patients treated with azathioprine and 6-mercaptopurine.Gut.2005 Aug;54(8):1121-5.
Comment:
Risk of lymphoma: inflammatory bowel disease and immunomodulators.Gut.2006 Apr;55(4):580-1.

What are the best treatment options for insulinoma [diazoxide, prednisolone, somatostatin analgs(octreotide), surgery)?

April 24th, 2008

1.  In Print in Falk Library: Neuroendocrinology. 2006;84(3):183-8. Epub 2007 Feb 20. Well-differentiated pancreatic tumor/carcinoma: insulinoma. de Herder WW, Niederle B, Scoazec JY, Pauwels S, Kloppel G, Falconi M, Kwekkeboom DJ, Oberg K, Eriksson B, Wiedenmann B, Rindi G, O’Toole D, Ferone D; Frascati Consensus Conference; European Neuroendocrine Tumor Society. Department of Internal Medicine, Section of Endocrinology, Erasmus MC, Rotterdam, The Netherlands.  Consensus Development Conference Guideline

2.   Curr Opin Oncol. 2008 Jan;20(1):25-33. Sporadically occurring functional pancreatic endocrine tumors: review of recent literature. Goldin SB, Aston J, Wahi MM.

3.   Best Pract Res Clin Gastroenterol. 2005 Oct;19(5):783-98. Insulinoma. Grant CS.

4.   Eur J Endocrinol. 2005 May;152(5):757-67. Octreotide in insulinoma patients: efficacy on hypoglycemia, relationships with Octreoscan scintigraphy and immunostaining with anti-sst2A and anti-sst5 antibodies. Vezzosi D, Bennet A, Rochaix P, Courbon F, Selves J, Pradere B, Buscail L, Susini C, Caron P.

5.  Ann Surg. 2008 Jan;247(1):165-72.  Improved contemporary surgical management of insulinomas: a 25-year experience at the Massachusetts General Hospital. Nikfarjam M, Warshaw AL, Axelrod L, Deshpande V, Thayer SP, Ferrone CR, Fernández-del Castillo C.

6.   Endocrinol Metab Clin North Am. 1999 Sep;28(3):533-54. Surgical aspects of hyperinsulinemic hypoglycemia. Grant CS.

What is the sensitivity and specificity of elevated ferritin levels in hemochromatosis?

April 24th, 2008

1.  Ann Intern Med. 2003 Apr 15;138(8):627-33. Erratum in: Ann Intern Med. 2003 Aug 5;139(3):235. Summary for patients in: Ann Intern Med. 2003 Apr 15;138(8):I1. Serum ferritin level predicts advanced hepatic fibrosis among U.S. patients with phenotypic hemochromatosis. Morrison ED, Brandhagen DJ, Phatak PD, Barton JC, Krawitt EL, El-Serag HB, Gordon SC, Galan MV, Tung BY, Ioannou GN, Kowdley KV.

 2.   In print at Falk library:  Can J Gastroenterol. 2006 Jul;20(7):467-70. The diversity of liver diseases among outpatient referrals for an elevated serum ferritin. Wong K, Adams PC. 

3.   Am J Med. 1995 Jun;98(6):566-71.   Extremely elevated serum ferritin levels in a university hospital: associated diseases and clinical significance. Lee MH, Means RT Jr.  

 4.  N Engl J Med. 2005 Apr 28;352(17):1769-78. Hemochromatosis and iron-overload screening in a racially diverse population. Adams PC, Reboussin DM, Barton JC, McLaren CE, Eckfeldt JH, McLaren GD, Dawkins FW, Acton RT, Harris EL, Gordeuk VR, Leiendecker-Foster C, Speechley M, Snively BM, Holup JL, Thomson E, Sholinsky P; Hemochromatosis and Iron Overload Screening (HEIRS) Study Research Investigators.

Liver disease in the population of middle age males who use ginseng compared to those who do not.

April 17th, 2008

Panax ginseng: a systematic review of adverse effects and drug interactions. Drug Saf. 2002;25(5):323-44.

Ginseng, Panax
RPS Herbal Medicines: A guide for Health-Care Professionals via MICROMEDEX

In patients with TB meningitis, treatment supplemented with glucocorticoids versus treatment without.

April 17th, 2008

Dexamethasone for the treatment of tuberculous meningitis in adolescents and adults. N Engl J Med. 2004 Oct 21;351(17):1741-51.
Comments:
Adjunctive steroids for tuberculous meningitis–more evidence, more questions.
N Engl J Med. 2004 Oct 21;351(17):1792-4.
Tuberculous meningitis. N Engl J Med. 2004 Oct 21;351(17):1719-20.
Dexamethasone for tuberculous meningitis. N Engl J Med. 2005 Feb 10;352(6):628-30; author reply 628-30.


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