November 18th, 2009

Wolff Parkinson White Syndrome associated with Seizures

Sproule DM, Kaufmann P, Engelstad K, Starc TJ, Hordof AJ, De Vivo DC. Wolff-Parkinson-White syndrome in Patients With MELAS. Arch Neurol. 2007 Nov;64(11):1625-7. PMID: 17998445

Hirano M, Ricci E, Koenigsberger MR, Defendini R, Pavlakis SG, DeVivo DC, DiMauro S, Rowland LP. Melas: an original case and clinical criteria for diagnosis. Neuromuscul Disord. 1992;2(2):125-35. PMID: 1422200 [not available electronically]

November 18th, 2009

Association of intracranial aneurysms and aortic coarctation

Lmejjati M et al. Intracranial aneurysm associated with aortic coarctation: a case report and literature review. Neurochirurgie 2007;53:100-103. [not available electronically]

Mercado R et al. Intracranial aneurysms associated with unsuspected aortic coarctation. J Neurosurg 2002;97(5):1221-1225.

November 17th, 2009

Primary Antiphospholipid Syndrome with Severe Mitral Regurgitation

Tenedios F, Erkan D, Lockshin MD. Cardiac manifestations in the antiphospholipid syndrome. Rheum Dis Clin North Am. 2006 Aug;32(3):491-507. Review. PubMed PMID: 16880080.

November 16th, 2009

What infections can be transmitted by rats?

Center for Disease Control and Prevention
Diseases from Rodents

Ordog GJ, Balasubramanium S, Wasserberger J. Rat bites: fifty cases. Ann Emerg Med. 1985 Feb;14(2):126-30. PubMed PMID: 3970397. [not available electronically]

Marx: Rosen’s Emergency Medicine, 7th ed. Chapter 58 – Mammalian Bites.

November 13th, 2009

Cholesterol crystal embolism, esp. secondary to endovascular procedures

Paraskevas KI, Koutsias S, Mikhailidis DP, Giannoukas AD. Cholesterol crystal embolization: a possible complication of peripheral endovascular interventions. J Endovasc Ther. 2008 Oct;15(5):614-25. Review. PubMed PMID: 18840042.

 Meyrier A. Cholesterol crystal embolism: diagnosis and treatment. Kidney Int. 2006 Apr;69(8):1308-12. Review. PubMed PMID: 16614719.

 Hagiwara N, Toyoda K, Nakayama M, Inoue T, Yasumori K, Ibayashi S, Okada Y.Renal cholesterol embolism in patients with carotid stenosis: a severe and underdiagnosed complication following cerebrovascular procedures. J Neurol Sci. 2004 Jul 15;222(1-2):109-12. PubMed PMID: 15240205.

 Fine MJ, Kapoor W, Falanga V. Cholesterol crystal embolization: a review of 221 cases in the English literature. Angiology. 1987 Oct;38(10):769-84. Review. PubMed PMID: 3310742.

November 12th, 2009

In patients that present with pulmonary embolism, what is the incidence of underlying malignancy? Are there characteristics that make malignancy more likely?

Lyman GH, Khorana AA. Cancer, clots and consensus: new understanding of an old problem. J Clin Oncol. 2009 Oct 10;27(29):4821-6. Epub 2009 Sep 14. Review. PubMed PMID: 19752337; PubMed Central PMCID: PMC2764390.

Hasenberg U, Paul T, Feuersenger A, Goyen M, Kröger K. Cancer patients and characteristics of pulmonary embolism. Eur J Radiol. 2009 Mar;69(3):478-82. Epub 2007 Dec 31. PubMed PMID: 18164888.

Kolomansky A, Hoffman R, Sarig G, Brenner B, Haim N. Prospective evaluation of patients hospitalized with venous thromboembolism: comparison between cancer and  non-cancer patients. Isr Med Assoc J. 2006 Dec;8(12):848-52. PubMed PMID: 17214102.

 van der Heiden PL, Prins MH, de Monyé W, van Strijen ML, Banga JD, Postmus PE, Ten Wolde M, Büller HR, Brandjes DP, Huisman MV; ANTELOPE study group. Pulmonary embolism as a first clinical sign of occult malignancy: a prospective follow-up study. Thromb Haemost. 2006 Mar;95(3):584-5. PubMed PMID: 16525594.

Lin J, Wakefield TW, Henke PK. Risk factors associated with venous thromboembolic events in patients with malignancy. Blood Coagul Fibrinolysis.2006 Jun;17(4):265-70. PubMed PMID: 16651868

November 10th, 2009

In patients with Essential Thrombocythemia or thrombocytosis, what is the optimal therapy and use of antiplatelet drugs?

 Squizzato A, Romualdi E, Middeldorp S. Antiplatelet drugs for polycythaemia vera and essential thrombocythaemia. Cochrane Database Syst Rev. 2008 Apr 16;(2):CD006503. Review. PubMed PMID: 18425953.

 De Stefano V, Za T, Rossi E, Vannucchi AM, Ruggeri M, Elli E, Micò C, Tieghi A, Cacciola RR, Santoro C, Gerli G, Vianelli N, Guglielmelli P, Pieri L, Scognamiglio F, Rodeghiero F, Pogliani EM, Finazzi G, Gugliotta L, Marchioli R, Leone G, Barbui T; GIMEMA CMD-Working Party. Recurrent thrombosis in patients with polycythemia vera and essential thrombocythemia: incidence, risk factors, and effect of treatments. Haematologica. 2008 Mar;93(3):372-80. Epub 2008 Feb 11. PubMed PMID: 18268279.

Barbui T, Finazzi G. When and how to treat essential thrombocythemia. N Engl J Med. 2005 Jul 7;353(1):85-6. PubMed PMID: 16000360.

 Harrison CN, Campbell PJ, Buck G, Wheatley K, East CL, Bareford D, Wilkins BS, van der Walt JD, Reilly JT, Grigg AP, Revell P, Woodcock BE, Green AR; United Kingdom Medical Research Council Primary Thrombocythemia 1 Study. Hydroxyurea compared with anagrelide in high-risk essential thrombocythemia. N Engl J Med. 2005 Jul 7;353(1):33-45. PubMed PMID: 16000354.

October 30th, 2009

In patients with myasthenia gravis, how often does myasthenic crisis accompany other signs or symptoms of muscle weakness, versus presenting with respiratory failure alone?

 QJM. 2009 Feb;102(2):97-107. Epub 2008 Dec 5.  Myasthenic crisis. Chaudhuri A, Behan PO.

Curr Neurol Neurosci Rep. 2005 Nov;5(6):476-82. Update on respiratory management of critically ill neurologic patients. Rabinstein AA.

Chest. 1990 Jan;97(1):232-4. Myasthenia gravis presenting as isolated respiratory failure. Dushay KM, Zibrak JD, Jensen WA.

October 28th, 2009

In patients with lymphoma, what is the prognosis when they present with hypercalcemia?

Blood. 1993 Sep 1;82(5):1383-94. Calcitriol: the major humoral mediator of hypercalcemia in Hodgkin’s disease and non-Hodgkin’s lymphomas.  Seymour JF, Gagel RF.

October 28th, 2009

In patients with lymphoma and hypercalcemia, what is the efficacy of zometa treatment in reducing calclium?

J Clin Oncol. 2001 Jan 15;19(2):558-67. Zoledronic acid is superior to pamidronate in the treatment of hypercalcemia of malignancy: a pooled analysis of two randomized, controlled clinical trials. Major P, Lortholary A, Hon J, Abdi E, Mills G, Menssen HD, Yunus F, Bell R, Body J, Quebe-Fehling E, Seaman J.


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