In patients with infiltrative Cardiomyopathy and a negative cardiac MRI what are the indications for endomyocardial biopsy?

September 5th, 2008

Cooper LT, Baughman KL, Feldman AM, Frustaci A, Jessup M, Kuhl U, Levine GN, Narula J, Starling RC, Towbin J, Virmani R; American Heart Association; American College of Cardiology; European Society of Cardiology.
The role of endomyocardial biopsy in the management of cardiovascular disease: a scientific statement from the American Heart Association, the American College of Cardiology, and the European Society of Cardiology.
Circulation. 2007 Nov 6;116(19):2216-33. Epub 2007 Oct 24.Ardehali H, Qasim A, Cappola T, Howard D, Hruban R, Hare JM, Baughman KL, Kasper EK.
Endomyocardial biopsy plays a role in diagnosing patients with unexplained cardiomyopathy.
Am Heart J. 2004 May;147(5):919-23.  Vogelsberg H, Mahrholdt H, Deluigi CC, Yilmaz A, Kispert EM, Greulich S, Klingel K, Kandolf R, Sechtem U.
Cardiovascular magnetic resonance in clinically suspected cardiac amyloidosis: noninvasive imaging compared to endomyocardial biopsy.
J Am Coll Cardiol. 2008 Mar 11;51(10):1022-30.

In patients with recurrent pleural effusions, what is the reaccumulation rate s/p pleuradesis versus no pleuradesis?

September 5th, 2008

Shaw P, Agarwal R.
Pleurodesis for malignant pleural effusions.
Cochrane Database Syst Rev. 2004;(1):CD002916.

Ukale V, Agrenius V, Hillerdal G, Mohlkert D, Widström O.
Pleurodesis in recurrent pleural effusions: a randomized comparison of a classical and a currently popular drug.
Lung Cancer. 2004 Mar;43(3):323-8. 

Sudduth CD, Sahn SA.

Pleurodesis for nonmalignant pleural effusions. Recommendations.
Chest. 1992 Dec;102(6):1855-60.

In patients with stage III, IV lupus nephritis what are treatment/management recommendations?

August 25th, 2008

Treatment of diffuse proliferative lupus nephritis: a meta-analysis of randomized controlled trials.
Flanc RS, Roberts MA, Strippoli GF, Chadban SJ, Kerr PG, Atkins RC.
Am J Kidney Dis. 2004 Feb;43(2):197-208
[* Note: Author indicates that the Data/content of this publication was extracted from the Cochrane review listed below]

Treatment for lupus nephritis.
Flanc RS, Roberts MA, Strippoli GF, Chadban SJ, Kerr PG, Atkins RC.
Cochrane Database Syst Rev. 2004;(1):CD002922. Review.

EULAR recommendations for the management of systemic lupus erythematosus. Report of a Task Force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics.
Bertsias G, Ioannidis JP, Boletis J, Bombardieri S, Cervera R, Dostal C, Font J, Gilboe IM, Houssiau F, Huizinga T, Isenberg D, Kallenberg CG, Khamashta M, Piette JC, Schneider M, Smolen J, Sturfelt G, Tincani A, van Vollenhoven R, Gordon C, Boumpas DT; Task Force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics.
Ann Rheum Dis. 2008 Feb;67(2):195-205. Epub 2007 May 15.

In patients with carotid artery dissection, what are the recommendations for prospective management? OR In patients with carotid artery dissection, how long do you anticoagulate?

August 25th, 2008

Antithrombotic drugs for carotid artery dissection.
Lyrer P, Engelter S.
Cochrane Database Syst Rev. 2003;(3):CD000255. Review.

Cervical arterial dissection: time for a therapeutic trial?
Beletsky V, Nadareishvili Z, Lynch J, Shuaib A, Woolfenden A, Norris JW; Canadian Stroke Consortium.
Stroke. 2003 Dec;34(12):2856-60. Epub 2003 Nov 6.

Dissection of cervical arteries: Long-term follow-up study of 130 cases.
Arauz A, Hoyos L, Espinoza C, Cantú C, Barinagarrementeria F, Román G.
Cerebrovasc Dis. 2006;22(2-3):150-4. Epub 2006 May 10.

In patients with hemolytic anemia what is the incidence of direct hyperbilirubinemia?

August 25th, 2008

Increased serum conjugated bilirubin in hemolytic
anemia.

Maldonado, JE, Kyle, RA, Schoenfield, LJ
Postgrad Med. 1974 Feb;55(2):183-7 passim.

Bilirubinuria, conjugated hyperbilirubinaemia and
delta bilirubinaemia following acute haemolysis.

Cummins, D, Ferrier, A, Murphy, F
Ann Clin Biochem. 1997 Jan;34 ( Pt 1):109-10.

In patients presenting with compression fractures what is the incidence of multiple myeloma?

August 25th, 2008

Retrospective review of biopsy results following percutaneous fixation of vertebral compression fractures.
Schoenfeld AJ, Dinicola NJ, Ehrler DM, Koerber A, Paxos M, Shorten SD, Bowers J, Jackson E, Smith MJ.
Injury
. 2008 Mar;39(3):327-33. Epub 2007 Sep 18.

Histological evaluation of biopsies obtained from vertebral compression fractures: unsuspected myeloma and osteomalacia.
Togawa D, Lieberman IH, Bauer TW, Reinhardt MK, Kayanja MM.

Spine
. 2005 Apr 1;30(7):781-6.

What is the risk/benefit for palliative hepatobiliary stenting and what are the indications for this type of stenting as well as incidence of placement?

August 20th, 2008

J Support Oncol. 2006 Jun;4(6):269-73. Palliative percutaneous drainage in malignant biliary obstruction. Part 1: indications and preprocedure evaluation. Covey AM, Brown KT.

J Support Oncol. 2006 Jul-Aug;4(7):329-35. Palliative percutaneous drainage in malignant biliary obstruction. Part 2: Mechanisms and postprocedure management. Covey AM, Brown KT.

Dig Liver Dis. 2007 Apr;39(4):375-88. Epub 2007 Feb 20. Endoscopic palliation of malignant obstructive jaundice: an evidence-based review. Cipolletta L, Rotondano G, Marmo R, Bianco MA; for the Italian Evidence-Based Gastroenterology & Hepatology Club.

Eur Radiol. 2008 Mar;18(3):448-56. Epub 2007 Oct 25. Percutaneous drainage and stenting for palliation of malignant bile duct obstruction. van Delden OM, Laméris JS.

J Hosp Med. 2008 Mar;3(2):117-23. Fate of patients with obstructive jaundice. Björnsson E, Gustafsson J, Borkman J, Kilander A.

What is the incidence/prevalence of abnormal liver function tests in HIV or EBV?

August 20th, 2008

Dig Dis Sci. 2008 May;53(5):1375-82. Epub 2007 Oct 16. The prevalence and risk factors for abnormal liver enzymes in HIV-positive patients without hepatitis B or C coinfections. Sterling RK, Chiu S, Snider K, Nixon D.

Epidemiol Infect. 2003 Aug;131(1):683-9. Clinical and laboratory presentation of EBV positive infectious mononucleosis in young adults. Grotto I, Mimouni D, Huerta M, Mimouni M, Cohen D, Robin G, Pitlik S, Green MS.

What is the sensitivity and specificiy of HIT panel and how do you treat HIT?

August 13th, 2008

N Engl J Med. 2006 Aug 24;355(8):809-17.  Clinical practice. Heparin-induced thrombocytopenia. Arepally GM, Ortel TL.

Semin Respir Crit Care Med. 2008 Feb;29(1):66-74. The approach to heparin-induced thrombocytopenia. Linkins LA, Warkentin TE.

What are diagnostic tests for hemorrhagic pericardial effusion/pericarditis?

August 13th, 2008

Heart. 2001 Aug;86(2):235-40. Management of pericardial effusion. Soler-Soler J, Sagristà-Sauleda J, Permanyer-Miralda G. 

Radiographics. 2003 Oct;23 Spec No:S167-80. CT and MR imaging of pericardial disease. Wang ZJ, Reddy GP, Gotway MB, Yeh BM, Hetts SW, Higgins CB.


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