CREME -- Cis-Regulatory Module Explorer for the Human Genome
What you can do:
Identify and visualize cis-regulatory modules in the promoter regions of a given set of potentially co-regulated genes in human genome.
Highlights:
- CREME relies on a database of putative transcription factor binding sites that have been annotated across the human genome using a library of position weight matrices and evolutionary conservation with the mouse and rat genomes.
- A search algorithm is applied to this data set to identify combinations of transcription factors whose binding sites tend to co-occur in close proximity in the promoter regions of the input gene set.
- The identified cis-regulatory modules are statistically scored and significant combinations are reported and graphically visualized.
Keywords:
- human transcription factor binding sites
- cis-elements
- DNA-binding sites
- transcription regulation
- promoter elements
- promoter analysis
- regulatory motifs
- human regulatory sequences
- human promoters
- human cis-elements
Literature & Tutorials:
PubMed Link: CREME
This record last updated: 05-09-2005