Search for information on protein domain structures and classification.
The latest version of CATH (class, architecture, topology, homology) contains 114,215 domains, 2178 Homologous superfamilies and 1110 fold groups.
20,330 new domains, 87 new homologous superfamilies and 26 new folds have been developed since CATH release version 3.1.
A total of 28,064 new domains have been assigned since CATH version 3.0.
The CATH website has been completely redesigned and includes more comprehensive documentation.
The CATHEDRAL structure comparison algorithm has been improved and used to characterize structural diversity in CATH superfamilies and structural overlaps between superfamilies.
Although the majority of superfamilies in CATH are not structurally diverse and do not overlap significantly with other superfamilies, approximately 4% of superfamilies are very diverse and these are the superfamilies that are most highly populated in both the PDB and in the genomes.
Information on the degree of structural diversity in each superfamily and structural overlaps between superfamilies can now be downloaded from the CATH website.