WebFEATURE -- an interactive web tool for identifying and visualizing functional sites on macromolecular structures
What you can do:
Scan query structures for functional sites in both proteins and nucleic acids.
Highlights:
- WebFEATURE is the public interface to the scanning algorithm of the FEATURE package, a supervised learning algorithm for creating and identifying 3D, physicochemical motifs in molecular structures.
- Given an input structure or Protein Data Bank identifier (PDB ID), and a statistical model of a functional site, WebFEATURE will return rank-scored 'hits' in 3D space that identify regions in the structure where similar distributions of physicochemical properties occur relative to the site model.
- Users can visualize and interactively manipulate scored hits and the query structure in web browsers that support the Chime plug-in.
- Alternatively, results can be downloaded and visualized through other freely available molecular modeling tools, like RasMol, PyMOL and Chimera.
- A major application of WebFEATURE is in rapid annotation of function to structures in the context of structural genomics.
Keywords:
- protein functional site scan tool
- protein functional sites
- nucleic acid functional site scan tool
- nucleic acid functional sites
- Calcium binding site scan tool
- ATP binding site scan tool
- Chloride binding site scan tool
- protein sequence analysis tool
- protein annotation tool
- nucleic acid sequence analysis tool
Literature & Tutorials:
This record last updated: 06-09-2005