PSORTb v.2.0 -- expanded prediction of bacterial protein subcellular localization and insights gained from comparative proteome analysis.
What you can do:
Predict bacterial protein subcellular localizations.
Highlights:
- PSORT-B examines a given protein sequence for amino acid composition, similarity to proteins of known localization, presence of a signal peptide, transmembrane alpha-helices and motifs corresponding to specific localizations.
- A probabilistic method integrates these analyses, returning a list of five possible localization sites with associated probability scores.
- The program attains a precision of 96% for Gram-positive and Gram-negative bacteria and predictive coverage comparable to other tools for whole proteome analysis.
- The proportion of proteins at each localization is remarkably consistent across species, even in species with varying proteome size.
- This dataset, the largest of its kind, is freely available, along with the PSORT-B source code
Keywords:
- protein localizations
- protein subcellular localizations
- signal peptide prediction tool
- protein localization prediction tool
- protein subcellular localization prediction tool
- bacterial protein subcellular localizations
- bacterial protein localizations
- Gram-negative bacteria
- Gram-positive bacteria
- signal peptide
- transmembrane alpha-helices
- localization signals
- localization signal prediction
This record last updated: 06-15-2005