Geno2pheno -- estimating phenotypic drug resistance from HIV-1 genotypes
What you can do:
Predict phenotypic resistance of the respective virus to 17 antiretroviral drugs.
Highlights:
- From a set of 650 matched genotype-phenotype pairs, regression models were constructed for the prediction of phenotypic drug resistance from genotypes.
- Since the range of resistance factors varies considerably between different drugs, two scoring functions are derived from different sets of predicted phenotypes.
- Both scores provide standardized measures of resistance that can be calculated from the genotype and are comparable between drugs.
- On submitting below an HIV-1 pol-gene DNA sequence, the user will obtain a sequence alignment to the reference strain HXB2, a list of mutations and different predictions of phenotypic resistance of the respective virus to 17 antiretroviral drugs.
- This web interface to geno2pheno is intended for single resistance predictions,not for screening of sequence databases.
Keywords:
- anti-HIV therapy
- antiretroviral therapy
- Genotypic resistance testing
- phenotypic resistance testing
- viral drug resistance
- HIV-1
- HIV Infections
- virus
- HIV-1 pol-gene
- single resistance prediction tool
Literature & Tutorials:
This record last updated: 04-24-2006