ConSurf-DB -- evolutionary conservation profiles of protein structures database
What you can do:
Automatically calculate evolutionary conservation scores of key amino acid residues and map them on protein structures.
Highlights:
- ConSurf-DB is a repository for evolutionary conservation analysis of the proteins of known structures in the Protein Data Bank (PDB).
- Sequence homologues of each of the PDB entries were collected and aligned using standard methods.
- The evolutionary conservation of each amino acid position in the alignment was calculated using the Rate4Site algorithm, implemented in the ConSurf web server.
- The algorithm takes into account the phylogenetic relations between the aligned proteins and the stochastic nature of the evolutionary process explicitly.
- Rate4Site assigns a conservation level for each position in the multiple sequence alignment using an empirical Bayesian inference.
- Visual inspection of the conservation patterns on the 3D structure often enables the identification of key residues that comprise the functionally important regions of the protein.
Keywords:
- protein sequence analysis tool
- protein conserved sequences
- protein functional sites
- protein binding sites
- protein catalytic sites
- protein functional site mapping tool
- protein evolution
Literature & Tutorials:
This record last updated: 02-25-2009