IARC Database of p53 gene mutations in human tumors and cell lines

URL:

http://www-p53.iarc.fr/index.html

What you can do:

Search for all TP53 gene mutations identified in human cancers and cell lines that have been reported in the peer-reviewed literature since 1989.

Highlights:

This database originally consisted of a list of somatic point mutations in the p53 gene of human tumors and cell lines, compiled from the published literature and made available in a standard electronic form.
The database compiles all mutations (somatic and inherited), as well as polymorphisms, that have been reported in the published literature since 1989.
New developments include restructuring of the database, which is now patient-centered, with more detailed annotations on the patient (carcinogen exposure, virus infection, genetic background).
A new on-line application to retrieve somatic mutation data and analyze mutation patterns is now available.
The IARC TP53 Mutation Database compiles all TP53 gene mutations identified in human cancers and cell lines that have been reported in the peer-reviewed literature since 1989.
The following datasets are available:
. TP53 somatic mutations in sporadic cancers
. TP53 germline mutation in familial cancers
. Common TP53 polymorphisms identified in human populations
. Functional properties of P53 mutant proteins
. TP53 gene status in human cell-lines

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This record last updated: 03-31-2006