COSMIC -- Catalogue of somatic mutations in cancer
What you can do:
Search for data and published information on human somatic mutation in cancer
Highlights:
- The catalogue of Somatic Mutations in Cancer (COSMIC) is a resource for information on somatically acquired mutations in human cancer.
- It contains details of 1.5-million experiments performed through 13,423 genes in almost 370,000 tumours, describing over 90,000 individual mutations.
- Data are gathered from two sources, publications in the scientific literature, (v43 contains 7797 curated articles) and the full output of the genome-wide screens from the Cancer Genome Project (CGP) at the Sanger Institute, UK.
- Whole-genome sequencing screens are now identifying large numbers of genomic rearrangements in cancer and COSMIC is now displaying details of these analyses also.
- Examination of COSMIC's data is primarily web-driven, focused on providing mutation range and frequency statistics based upon a choice of gene and/or cancer phenotype.
- Graphical views provide easily interpretable summaries of large quantities of data, and export functions can provide precise details of user-selected data.
Keywords:
- human somatic mutation
- Proto-Oncogene Proteins
- human cancer cell lines
- human neoplasms
- human mutations
Literature & Tutorials:
PubMed Link: The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website
-- 2005 update: COSMIC 2005
-- 2010 update: COSMIC 2005
2011 Update: COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer.
-- 2005 update: COSMIC 2005
-- 2010 update: COSMIC 2005
2011 Update: COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer.
This record last updated: 03-15-2010