LymphTF DB
What you can do:
A portal of information regarding transcription factor (TF) activity in the developing B and T cells (lymphocytes) in the mouse.
Highlights:
- B and T cells develop following a similar early stepwise progression to later stages where multiple developmental options are available. These developmental regimes necessitate differential gene expression regulated by a large number of transcription factors (TFs). The resultant burgeoning amount of information has opened a knowledge gap between TF activities during lymphocyte development and a researcher's experiments. We have created the LymphTF database (DB) to fill this gap. This DB holds interactions between individual TFs and their specific targets at a given developmental time. By storing such interactions as a function of developmental progression, we hope to advance the elucidation of regulatory networks that guide lymphocyte development. Besides queries for TF-target gene interactions in developmental stages, the DB provides a graphical representation of downloadable target gene regulatory sequences with locations of the transcriptional start sites and TF-binding sites.
Keywords:
- transcription Factors
- B cell
- T cell
- Development
- gene regulation
- expression
- developmental biology
- lymphocyte development
- Targets
- mouse
- TF
Literature & Tutorials:
This record last updated: 05-03-2007