Evola -- human orthologs as evolutionary annotation

URL:
http://www.h-invitational.jp/evola/
What you can do:
Database of evolutionary features of human genes.
Highlights:
  • A sub-database of H-InvDB, an integrated database of annotated human genes (http://h-invitational.jp/).
  • In the process of the ortholog detection, computational analysis based on conserved genome synteny and transcript sequence similarity was followed by manual curation by researchers examining phylogenetic trees.
  • In total, 18 968 human genes have orthologs among 11 vertebrates (chimpanzee, mouse, cow, chicken, zebrafish, etc.), either computationally detected or manually curated orthologs.
  • Evola provides amino acid sequence alignments and phylogenetic trees of orthologs and homologs.
  • In 'd(N)/d(S) view', natural selection on genes can be analyzed between human and other species.
  • In 'Locus maps', all transcript variants and their exon/intron structures can be compared among orthologous gene loci.
  • We expect the Evola to serve as a comprehensive and reliable database to be utilized in comparative analyses for obtaining new knowledge about human genes.
Keywords:
  • Phylogeny
  • Synteny
  • ortholog
  • orthologous
  • orthologs
  • homologs
  • transcript sequence similarity
  • phylogenetic tree
  • amino acid sequence alignments
Literature & Tutorials:
PubMed Link: Evola: Ortholog database of all human genes in H-InvDB with manual curation of phylogenetic trees
This record last updated: 05-02-2008
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