The Gibbs Centroid Sampler
What you can do:
Locate conserved elements in biopolymer sequences.
Highlights:
- The Gibbs Centroid Sampler reports a centroid alignment, i.e. an alignment that has the minimum total distance to the set of samples chosen from the a posteriori probability distribution of transcription factor binding-site alignments.
- In so doing, it garners information from the full ensemble of solutions, rather than only the single most probable point that is the target of many motif-finding algorithms, including its predecessor, the Gibbs Recursive Sampler.
- Centroid estimators have been shown to yield substantial improvements, in both sensitivity and positive predictive values, to the prediction of RNA secondary structure and motif finding.
Keywords:
- Repetitive Sequences,
- Sequence Analysis
- Transcription Factors
- Transcription Initiation Site
- centroid
- conserved elements
- motif
Literature & Tutorials:
PubMed Link: The Gibbs Centroid Sampler
This record last updated: 06-04-2008