CellLine -- a stochastic cell lineage simulator
What you can do:
A simulator of the dynamics of gene regulatory networks (GRN) in the cells of a lineage.
Highlights:
- From user-defined reactions and initial substance quantities, it generates cell lineages, i.e. genealogic pedigrees of cells related through mitotic division.
- Each cell's dynamics is driven by a delayed stochastic simulation algorithm (delayed SSA), allowing multiple time delayed reactions.
- The cells of the lineage can be individually subject to 'perturbations', such as gene deletion, duplication and mutation.
- External interventions, such as adding or removing a substance at a given moment, can be specified.
- Cell differentiation lineages, where differentiation is stochastically driven or externally induced, can be modeled as well.
- Finally, CellLine can generate and simulate the dynamics of multiple copies of any given cell of the lineage.
Keywords:
- Cell Differentiation
- Stochastic Processes
- cell lineage
- gene regulatory networks
- GRN
- lineage
- cell dynamics
Literature & Tutorials:
PubMed Link: CellLine, a stochastic cell lineage simulator
This record last updated: 08-07-2008