Degradome -- database of mammalian proteases and diseases of proteolysis
What you can do:
Find information on proteases and proteolysis.
Highlights:
- The degradome is defined as the complete set of proteases present in an organism.
- The recent availability of whole genomic sequences from multiple organisms has led us to predict the contents of the degradomes of several mammalian species.
- To ensure the fidelity of these predictions, our methods have included manual curation of individual sequences and, when necessary, direct cloning and sequencing experiments.
- The results of these studies in human, chimpanzee, mouse and rat have been incorporated into the Degradome database.
- The annotations about each individual protease can be retrieved by browsing catalytic classes and families or by searching specific terms.
- This web site also provides detailed information about genetic diseases of proteolysis, a growing field of great importance for multiple users.
- Finally, the user can find additional information about protease structures, protease inhibitors, ancillary domains of proteases and differences between mammalian degradomes.
Keywords:
- proteolysis
- protease
- human genome
- chimpanzee genome
- mouse genome
- rat genome
- degradome
Literature & Tutorials:
This record last updated: 09-15-2008