TIARA -- Total Integrated Archive of Short-Read and Array
What you can do:
Perform analysis on personal genomes.
Highlights:
- TIARA is a database which contains personal genomic information obtained from next generation sequencing (NGS) techniques and ultra-high-resolution comparative genomic hybridization (CGH) arrays.
- High-throughput genomic technologies have been used to explore personal human genomes for the past few years.
- Although the integration of technologies is important for high-accuracy detection of personal genomic variations, no databases have been prepared to systematically archive genomes and to facilitate the comparison of personal genomic data sets prepared using a variety of experimental platforms.
- This database improves the accuracy of detecting personal genomic variations, such as SNPs, short indels and structural variants (SVs).
- At present, 36 individual genomes have been archived and may be displayed in the database. TIARA supports a user-friendly genome browser, which retrieves read-depths (RDs) and log2 ratios from NGS and CGH arrays, respectively.
- In addition, this database provides information on all genomic variants and the raw data, including short reads and feature-level CGH data, through anonymous file transfer protocol.
- More personal genomes will be archived as more individuals are analyzed by NGS or CGH array.
- TIARA provides a new approach to the accurate interpretation of personal genomes for genome research.
Keywords:
- personal genome
- human genome
Literature & Tutorials:
This record last updated: 06-14-2011