PROMISCUOUS -- Comprehensive Drug-Repositioning Database
What you can do:
Find information about drugs, proteins and side effects.
Highlights:
- PROMISCUOUS is a database containing an exhaustive set of drugs (25,000), including withdrawn or experimental drugs, annotated with drug-protein and protein-protein relationships (21,500/104,000) compiled from public resources via text and data mining including manual curation.
- It is intended to address the interest in systematically elucidating new areas of application for known drugs.
- The knowledge, understanding and prediction of so-called off-target effects allow a rational approach to the understanding of side-effects.
- Measures of structural similarity for drugs as well as known side-effects can be easily connected to protein-protein interactions to establish and analyse networks responsible for multi-pharmacology.
- This network-based approach can provide a starting point for drug-repositioning.
Keywords:
- drug repositioning
- drug side effects
- protein-protein interaction
- protein-drug interaction
- drug-protein interaction
- experimental drug
- withdrawn drug
- drug side effect
Literature & Tutorials:
This record last updated: 06-14-2011