Protegen -- PROTEctive antiGEN database
What you can do:
Highlights:
- Protegen is a web-based central database and analysis system that curates, stores and analyzes protective antigens.
- Basic antigen information and experimental evidence are curated from peer-reviewed articles.
- More detailed gene/protein information (e.g. DNA and protein sequences, and COG classification) are automatically extracted from existing databases using internally developed scripts.
- Bioinformatics programs are also applied to compute different antigen features, such as protein weight and pI, and subcellular localizations of bacterial proteins.
- Presently, 590 protective antigens have been curated against over 100 infectious diseases caused by pathogens and non-infectious diseases (including cancers and allergies).
- A web query and visualization interface is developed for interactive protective antigen search.
- A customized BLAST sequence similarity search is also developed for analysis of new sequences provided by the users.
- To support data exchange, the information of protective antigens is stored in the Vaccine Ontology (VO) in OWL format and can also be exported to FASTA and Excel files.
Keywords:
- protective antigen
- antigen
- infectious disease
- immune response
- immune system
- vaccine development
Literature & Tutorials:
This record last updated: 06-14-2011