What you can do:
Identify protein families and domains for a given protein sequence.
  • PROSITE consists of documentation entries describing protein domains, families and functional sites, as well as associated patterns and profiles to identify them.
  • It is complemented by ProRule, a collection of rules based on profiles and patterns, which increases the discriminatory power of these profiles and patterns by providing additional information about functionally and/or structurally critical amino acids.
  • PROSITE is largely used for the annotation of domain features of UniProtKB/Swiss-Prot entries.
  • Among the 983 (DNA-binding) domains, repeats and zinc fingers present in Swiss-Prot (release 57.8 of 22 September 2009), 696 ( approximately 70%) are annotated with PROSITE descriptors using information from ProRule.
  • In order to allow better functional characterization of domains, PROSITE developments focus on subfamily specific profiles and a new profile building method giving more weight to functionally important residues.
  • The latest release includes AMSA, an annotated multiple sequence alignment format used to build a new generation of generalized profiles, the migration of ScanProsite to Vital-IT, a cluster of 633 CPUs, and the adoption of the Distributed Annotation System (DAS) to facilitate PROSITE data integration and interchange with other sources.
  • The latest version of PROSITE (release 20.54, of 22 September 2009) contains 1308 patterns, 863 profiles and 869 ProRules.
  • protein domains
  • protein families
  • protein patterns
  • protein profiles
  • protein signatures
  • protein functional sites
  • 3D protein structures
  • prorule
This record last updated: 01-25-2010
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