PROSITE
What you can do:
Identify protein families and domains for a given protein sequence.
Highlights:
- PROSITE consists of documentation entries describing protein domains, families and functional sites, as well as associated patterns and profiles to identify them.
- It is complemented by ProRule, a collection of rules based on profiles and patterns, which increases the discriminatory power of these profiles and patterns by providing additional information about functionally and/or structurally critical amino acids.
- PROSITE is largely used for the annotation of domain features of UniProtKB/Swiss-Prot entries.
- Among the 983 (DNA-binding) domains, repeats and zinc fingers present in Swiss-Prot (release 57.8 of 22 September 2009), 696 ( approximately 70%) are annotated with PROSITE descriptors using information from ProRule.
- In order to allow better functional characterization of domains, PROSITE developments focus on subfamily specific profiles and a new profile building method giving more weight to functionally important residues.
- The latest release includes AMSA, an annotated multiple sequence alignment format used to build a new generation of generalized profiles, the migration of ScanProsite to Vital-IT, a cluster of 633 CPUs, and the adoption of the Distributed Annotation System (DAS) to facilitate PROSITE data integration and interchange with other sources.
- The latest version of PROSITE (release 20.54, of 22 September 2009) contains 1308 patterns, 863 profiles and 869 ProRules.
Keywords:
- protein domains
- protein families
- protein patterns
- protein profiles
- protein signatures
- protein functional sites
- 3D protein structures
- prorule
Literature & Tutorials:
PubMed Link: Recent improvements to the PROSITE database
-- 2006 Update: The PROSITE database
-- 2008 Update: The 20 years of PROSITE
-- 2010 Update: PROSITE, a protein domain database for functional characterization and annotation
-- 2006 Update: The PROSITE database
-- 2008 Update: The 20 years of PROSITE
-- 2010 Update: PROSITE, a protein domain database for functional characterization and annotation
This record last updated: 01-25-2010