ScanSite 2.0 -- Proteome-wide prediction of cell signaling interactions using short sequence motifs

What you can do:
Search for motifs within proteins that are likely to be phosphorylated by specific protein kinases or bind to domains such as SH2 domains, 14-3-3 domains or PDZ domains.
Highlights:
  • Optimal phosphorylation sites for particular protein Ser/Thr kinases or protein-Tyr kinases are predicted using the matrix of selectivity values for amino acids at each position relative to the phosphorylation site as determined from the oriented peptide library technique.
  • Optimal binding sites for SH2 domains, PDZ domains, 14-3-3 domains and other domains are determined using the matrix of selectivity values for amino acids at each position relative to an orienting residue as determined by the oriented peptide library technique.
Keywords:
  • Motif Scan tool
  • protein motif searching tool
  • signaling domains
  • protein motifs
  • 14-3-3 domains
  • phosphorylation sites
  • phosphorylation sites prediction tool
  • Ser/Thr kinases
  • protein-Tyr kinases
  • protein modification sites
  • post-translational modifications
This record last updated: 05-25-2005
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