KNOTTIN -- the knottin or inhibitor cystine knot scaffold
What you can do:
Search for dynamically generated tabular reports or sequence alignments for knottin three-dimensional structures or sequences.
Highlights:
- The KNOTTIN database provides standardized information on the small disulfide-rich proteins with a knotted topology called knottins or inhibitor cystine knots.
- Static pages present the essential historical or recent results about knottin discoveries, sequences, structures, syntheses, folding, functions, applications and bibliography.
- New tools, KNOTER3D and KNOTER1D, are provided to determine or predict if a user query (3D structure or sequence) is a knottin.
- These tools are now used to automate the database update.
- All knottin structures and sequences in the database are now standardized according to the knottin nomenclature based on loop lengths between knotted cysteines, and to the knottin numbering scheme.
- Therefore, the whole KNOTTIN database (sequences and structures) can now be searched using loop lengths, in addition to keyword and sequence (BLAST, HMMER) searches.
- Renumbered and structurally fitted knottin PDB files are available for download as well as renumbered sequences, sequence alignments and logos.
- The knottin numbering scheme is used for automatic drawing of standardized two-dimensional Colliers de Perles of any knottin structure or sequence in the database or provided by the user.
Keywords:
- knottin
- cystine knots
- protein structures
- protein engineering
- drug design
- inhibitor cystine knots
Literature & Tutorials:
This record last updated: 03-07-2008