DEQOR -- A Web-based Tool for the Design and Quality Control of siRNAs
What you can do:
Design siRNAs for RNAi with quality control.
Highlights:
- DEQOR uses a scoring system based on state-of-the-art parameters for siRNA design to evaluate the inhibitory potency of siRNAs.
- DEQOR can help to predict (i) regions in a gene that show high silencing capacity based on the base pair composition and (ii) siRNAs with high silencing potential for chemical synthesis.
- In addition, each siRNA arising from the input query is evaluated for possible cross-silencing activities by performing BLAST searches against the transcriptome or genome of a selected organism. DEQOR can therefore predict the probability that an mRNA fragment will cross-react with other genes in the cell and helps researchers to design experiments to test the specificity of esiRNAs or chemically designed siRNAs.
Keywords:
- RNA interference
- RNAi
- siRNA design tools
- small interfering RNAs
- siRNA
- sRNA
- endoribonuclease-prepared siRNAs
- esiRNAs
- dsRNA
Literature & Tutorials:
PubMed Link: DEQOR
This record last updated: 04-21-2014