Sfold --Statistical Folding and Rational Design of Nucleic Acids
What you can do:
Design RNA-targeting nucleic acids, which include small interfering RNAs (siRNAs), antisense oligonucleotides and trans-cleaving ribozymes for gene knock-down studies.
Highlights:
- siRNA design is based on a combination of RNA target accessibility prediction, siRNA duplex thermodynamic properties and empirical design rules. Its approach to target accessibility evaluation is an original extension of the underlying RNA folding algorithm to account for the likely existence of a population of structures for the target mRNA.
- In addition to the application modules Sirna, Soligo and Sribo for siRNAs, antisense oligos and ribozymes, respectively, the module Srna offers comprehensive features for statistical representation of sampled structures.
Keywords:
- RNA interference
- siRNA
- antisense oligos
- ribozymes
- RNA structures
- Knock-down studies
- Small Interfering RNAs
- siRNA
- si RNA
- siRNA design tools
- knock down expression
- RNAi
- gene silencing
Literature & Tutorials:
PubMed Link: Sfold
This record last updated: 05-06-2005