NRPS-PKS -- A Knowledge-based Resource for Analysis of NRPS/PKS Megasynthases

What you can do:
Analyze large multi-enzymatic, multi-domain megasynthases that are involved in the biosynthesis of pharmaceutically important natural products such as cyclosporin, rifamycin and erythromycin.
Highlights:
  • Apart from correct identification of NRPS and PKS domains, NRPS-PKS can also predict specificities of adenylation and acyltransferase domains with reasonably high accuracy, making it a valuable resource for identification of natural products biosynthesized by NRPS/PKS gene clusters found in newly sequenced genomes.
  • NRPS-PKS is a unique resource which provides a user-friendly interface for correlating chemical structures of natural products with the domains and modules in the corresponding nonribosomal peptide synthetases or polyketide synthases.
  • It also provides guidelines for domain/module swapping as well as site-directed mutagenesis experiments to engineer biosynthesis of novel natural products.
Keywords:
  • megasynthases
  • nonribosomal peptide synthetases
  • NRPS
  • polyketide synthases
  • protein domains
  • adenylation domains
  • acyltransferase domains
  • enzymes
  • cyclosporin biosynthesis
  • rifamycin biosynthesis
  • erythromycin biosynthesis
  • antibiotics biosynthesis
Literature & Tutorials:
PubMed Link: NRPS-PKS
This record last updated: 05-11-2005
Report a missing or misdirected URL.

The Health Sciences Library System supports the Health Sciences at the University of Pittsburgh.

© 1996 - 2023 Health Sciences Library System, University of Pittsburgh. All rights reserved.