Predict residues in protein sequences that determine the proteins' functional specificity.
Highlights:
It is designed for analysis of protein families whose members have biochemically similar but not identical interaction partners (e.g. different substrates for a family of transporters).
SDPpred predicts residues that could be responsible for the proteins' choice of their correct interaction partners.
The input of SDPpred is a multiple alignment of a protein family divided into a number of specificity groups, within which the interaction partner is believed to be the same.
SDPpred does not require information about the secondary or three-dimensional structure of proteins. It produces a set of the alignment positions (specificity determining positions) that determine differences in functional specificity.