IMGT/V-QUEST -- Immunoglobulin and T Cell Receptor Vx96J and Vx96Dx96J Rearrangement Analysis
What you can do:
A highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis.
Highlights:
- IMGT/V-QUEST identifies the variable (V), diversity (D) and joining (J) genes and alleles by alignment with the germline IG and TR gene and allele sequences of the IMGT reference directory.
- New functionalities were added through a complete rewrite in Java.
- IMGT/V-QUEST analyses batches of sequences (up to 50) in a single run.
- IMGT/V-QUEST describes the V-REGION mutations and identifies the hot spot positions in the closest germline V gene.
- IMGT/V-QUEST can detect insertions and deletions in the submitted sequences by reference to the IMGT unique numbering.
- IMGT/V-QUEST integrates IMGT/JunctionAnalysis for a detailed analysis of the V-J and V-D-J junctions, and IMGT/Automat for a full V-J- and V-D-J-REGION annotation.
- IMGT/V-QUEST displays, in 'Detailed view', the results and alignments for each submitted sequence individually and, in 'Synthesis view', the alignments of the sequences that, in a given run, express the same V gene and allele.
- The 'Advanced parameters' allow to modify default parameters used by IMGT/V-QUEST and IMGT/JunctionAnalysis according to the users' interest.
Keywords:
- immunoglobulin
- IG
- T cell receptors
- TR
- V-J junctions
- V-D-J junctions
- IG rearranged sequences
- V genes
- D genes
- J genes
- Gene Rearrangement
- Immunoglobulin Variable Region
Literature & Tutorials:
This record last updated: 04-21-2014