The Lipase Engineering Database -- A navigation and analysis tool for protein families

What you can do:
Search for information on sequence, structure, and function of lipases, esterases, and related proteins.
  • Sequence data on 806 protein entries are assigned to 38 homologous families, which are grouped into 16 superfamilies with no global sequence similarity between each other.
  • For each family, multisequence alignments are provided with functionally relevant residues annotated. Pre-calculated phylogenetic trees allow navigation inside superfamilies. Experimental structures of 45 proteins are superposed and consistently annotated.
  • The LED has been applied to systematically analyze sequencex96structurex96function relationships of this vast and diverse enzyme class.
  • It is a useful tool to identify functionally relevant residues apart from the active site residues, and to design mutants with desired substrate specificity.
  • lipases
  • esterases
  • Cutinases
  • Non-heme peroxidases
  • Carboxylesterases
  • enzymes
  • protein engineering
  • substrate specificity
  • phylogenetic trees
  • protein structures
  • multiple sequence alignments
Literature & Tutorials:
PubMed Link: LED
This record last updated: 05-23-2005
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