The Lipase Engineering Database -- A navigation and analysis tool for protein families
What you can do:
Search for information on sequence, structure, and function of lipases, esterases, and related proteins.
Highlights:
- Sequence data on 806 protein entries are assigned to 38 homologous families, which are grouped into 16 superfamilies with no global sequence similarity between each other.
- For each family, multisequence alignments are provided with functionally relevant residues annotated. Pre-calculated phylogenetic trees allow navigation inside superfamilies. Experimental structures of 45 proteins are superposed and consistently annotated.
- The LED has been applied to systematically analyze sequencex96structurex96function relationships of this vast and diverse enzyme class.
- It is a useful tool to identify functionally relevant residues apart from the active site residues, and to design mutants with desired substrate specificity.
Keywords:
- lipases
- esterases
- Cutinases
- Non-heme peroxidases
- Carboxylesterases
- enzymes
- protein engineering
- substrate specificity
- phylogenetic trees
- protein structures
- multiple sequence alignments
Literature & Tutorials:
PubMed Link: LED
This record last updated: 05-23-2005