PANTHER --Protein Analysis THrough Evolutionary Relationships

What you can do:
Browse and search proteins based on their biological functions.
Highlights:
  • Protein Analysis THrough Evolutionary Relationships (PANTHER) is a comprehensive software system for inferring the functions of genes based on their evolutionary relationships.
  • Phylogenetic trees of gene families form the basis for PANTHER and these trees are annotated with ontology terms describing the evolution of gene function from ancestral to modern day genes.
  • One of the main applications of PANTHER is in accurate prediction of the functions of uncharacterized genes, based on their evolutionary relationships to genes with functions known from experiment.
  • It also includes software tools for analyzing genomic data relative to known and inferred gene functions.
  • Since 2007, there have been several new developments to PANTHER: (i) improved phylogenetic trees, explicitly representing speciation and gene duplication events, (ii) identification of gene orthologs, including least diverged orthologs (best one-to-one pairs), (iii) coverage of more genomes (48 genomes), (iv) improved support for alternative database identifiers for genes, proteins and microarray probes and (v) adoption of the SBGN standard for display of biological pathways.
  • PANTHER trees are being annotated with gene function as part of the Gene Ontology Reference Genome project, resulting in an increasing number of curated functional annotations.
Keywords:
  • protein functions
  • protein families
  • protein classifications
  • phylogeny
  • protein phylogenetic trees
  • human genome
  • protein sequence alignments
  • Drosophila melanogaster genome
  • high-throughput analysis
  • protein sequence analysis
  • regulatory pathways
  • signal transduction pathways
  • metabolic pathways
This record last updated: 01-25-2010
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