NLSdb -- Database of nuclear localization signals

What you can do:
Search for information on nuclear localization signals (NLSs) and nuclear proteins.
  • NLSdb is a database of nuclear localization signals (NLSs) and of nuclear proteins targeted to the nucleus by NLS motifs.
  • The database contains 114 experimentally determined NLSs that were obtained through an extensive literature search. Using x91in silico mutagenesisx92 this set was extended to 308 experimental and potential NLSs. This final set matched over 43% of all known nuclear proteins and matches no currently known non-nuclear protein.
  • NLSdb contains over 6000 predicted nuclear proteins and their targeting signals from the PDB and SWISS-PROT/TrEMBL databases.
  • The database also contains over 12 500 predicted nuclear proteins from six entirely sequenced eukaryotic proteomes (Homo sapiens, Mus musculus, Drosophila melanogaster, Caenorhabditis elegans, Arabidopsis thaliana and Saccharomyces cerevisiae).
  • NLS motifs often co-localize with DNA-binding regions. This observation was used to also annotate over 1500 DNA-binding proteins.
  • nuclear localization signals
  • NLS
  • NLS motifs
  • nuclear import
  • nuclear proteins
  • nuclear protein prediction
  • DNA-binding proteins
Literature & Tutorials:
PubMed Link: NLSdb
This record last updated: 04-21-2014
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