The CATH database -- Class, Architecture, Topology, and Homology Protein Structure Database
What you can do:
Search for information on protein domain structures and classification.
Highlights:
- The latest version of CATH (class, architecture, topology, homology) contains 114,215 domains, 2178 Homologous superfamilies and 1110 fold groups.
- 20,330 new domains, 87 new homologous superfamilies and 26 new folds have been developed since CATH release version 3.1.
- A total of 28,064 new domains have been assigned since CATH version 3.0.
- The CATH website has been completely redesigned and includes more comprehensive documentation.
- The CATHEDRAL structure comparison algorithm has been improved and used to characterize structural diversity in CATH superfamilies and structural overlaps between superfamilies.
- Although the majority of superfamilies in CATH are not structurally diverse and do not overlap significantly with other superfamilies, approximately 4% of superfamilies are very diverse and these are the superfamilies that are most highly populated in both the PDB and in the genomes.
- Information on the degree of structural diversity in each superfamily and structural overlaps between superfamilies can now be downloaded from the CATH website.
Keywords:
- protein domains
- protein domain structures
- protein domain classifications
- protein structures
- protein families
- protein folds
Literature & Tutorials:
PubMed Link: CATH
-- 2005 update: CATH 2005 Update
-- 2007 update: The CATH domain structure database: new protocols and classification levels give a more comprehensive resource for exploring evolution
-- 2009 update: The CATH classification revisited--architectures reviewed and new ways to characterize structural divergence in superfamilies
2011 Update: Extending CATH: increasing coverage of the protein structure universe and linking structure with function.
-- 2005 update: CATH 2005 Update
-- 2007 update: The CATH domain structure database: new protocols and classification levels give a more comprehensive resource for exploring evolution
-- 2009 update: The CATH classification revisited--architectures reviewed and new ways to characterize structural divergence in superfamilies
2011 Update: Extending CATH: increasing coverage of the protein structure universe and linking structure with function.
This record last updated: 04-15-2009