eF-site -- Electrostatic surface of Functional site
What you can do:
Identify the protein surface around the functional site and to estimate the biochemical function.
Highlights:
- Molecular surfaces of protein molecules were computed based on the atom coordinates, and the eF-site database was prepared by adding the physical properties on the constructed molecular surfaces. The electrostatic potential on each molecular surface was individually calculated solving the Poisson-Boltzmann equation numerically for the precise continuum model, and the hydrophobicity information of each residue was also included.
- There are four different databases, eF-site/antibody, eF-site/prosite, eF-site/P-site, and eF-site/ActiveSite, corresponding to the antigen binding sites of antibodies with the same orientations, the molecular surfaces for the individual motifs in PROSITE database, the phosphate binding sites, and the active site surfaces for the representatives of the individual protein family, respectively.
- The method identifies the active site having the similar function to those of the known proteins.
Keywords:
- protein surface
- protein active sites
- protein functional sites
- protein structure-function analysis
- antigen binding sites
- phosphate binding sites
- protein motifs
- protein surface
- protein function prediction
Literature & Tutorials:
PubMed Link: eF-site
This record last updated: 05-12-2005