Analyze and compare homologous protein families in a multiple sequence alignment database of either known or unknown structure.
Highlights:
The present SUPFAM update (1.5) has been derived using Pfam (version 14.0), a database of sequence domains, and PALI (release 2.3) which is an alignment database of homologous proteins of known structure that is derived largely from SCOP.
2385 Pfam families could be connected to PALI/SCOP families and also cluster 114 Pfam families of apparently unknown structural information into 44 potential new superfamily. 2001 (~88%) of PALI families could also be related to Pfam families.