SpliceInfo -- An information repository for mRNA alternative splicing in human genome

What you can do:
Search for occurrences of the four major alternative-splicing modes in human genome.
Highlights:
  • The four major alternative-splicing modes in human genome include exon skipping, 5'-alternative splicing, 3'-alternative splicing and intron retention.
  • The dataset is derived by comparing the nucleotide and protein sequences available for a given gene for evidence of AS.
  • Additional features such as the tissue specificity of the mRNA, the protein domain contained by exons, the GC-ratio of exons, the repeats contained within the exons, and the Gene Ontology are annotated computationally for each exonic region that is alternatively spliced.
  • This resource also provides a means of identifying motifs candidates and this should help to identify potential regulatory mechanisms within a particular exonic sequence set and its two flanking intronic sequence sets. This is carried out using motif discovery tools to identify motif candidates related to alternative splicing regulation and together with a secondary structure prediction tool, will help in the identification of the structural properties of such regulatory motifs.
Keywords:
  • alternative splicing events
  • human alternative splicing
  • human introns
  • human exons
  • human gene splicing
  • regulatory motifs
  • exonic splicing enhancer
  • ESE
  • exonic splicing silencer
  • ESS
Literature & Tutorials:
PubMed Link: SpliceInfo
This record last updated: 05-10-2005

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