The MAPPER database -- A multi-genome catalog of putative transcription factor binding sites

What you can do:
Search for putative transcription factor binding sites in multiple genomes (human, mouse and D. melanogaster).
Highlights:
  • The putative transcription factor binding sites (TFBSs) across multiple genomes are created using a search method that relies on hidden Markov models built from experimentally determined TFBSs.
  • Using the information in the TRANSFAC and JASPAR databases, we built 1134 models for TFBSs and used them to scan regions 10 kb upstream of the start of the transcript for all known genes in the human, mouse and Drosophila melanogaster genomes.
  • The results, together with homology information on clusters of ortholog genes across the three genomes, were used to create a multi-organism catalog of annotated TFBSs.
  • The database allows the identification, visualization and selection of TFBSs occurring in the promoter of a gene of interest and also the common factors predicted to bind across the cluster of orthologs that includes that gene.
  • Alternatively, the interface allows the user to retrieve binding sites for a single transcription factor of interest in a single gene or in all genes of the human, mouse or fruit fly genomes.
Keywords:
  • transcription factor binding sites
  • DNA-binding sites
  • promoter analysis
  • promoter elements
  • regulatory sequences
  • regulatory elements
  • human transcription factor binding sites
  • mouse transcription factor binding sites
  • fruit fly transcription factor binding sites
Literature & Tutorials:
PubMed Link: MAPPER
This record last updated: 05-09-2005
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