Virulence Factor Database (VFDB) -- an enhanced web-based resource for comparative pathogenomics
What you can do:
Search for current knowledge about virulence factors (VFs) from various bacterial pathogens.
Highlights:
- Virulence factor database (VFDB) was set up in 2004 dedicated for providing current knowledge of virulence factors (VFs) from various medical significant bacterial pathogens to facilitate pathogenomic research.
- Nowadays, complete genome sequences of almost all the major pathogenic microbes have been determined, which makes comparative genomics a powerful approach for uncovering novel virulence determinants and hidden aspects of pathogenesis.
- VFDB was therefore upgraded to present the enormous diversity of bacterial genomes in terms of virulence genes and their organization.
- The VFDB 2008 release includes the following new features; (i) detailed tabular comparison of virulence composition of a given genome with other genomes of the same genus, (ii) multiple alignments and statistical analysis of homologous VFs and (iii) graphical comparison of genomic organizations of virulence genes.
- Comparative analysis of the numerous VFs will improve our understanding of the nature and evolution of virulence, as well as the development of new therapeutic and preventive strategies.
Keywords:
- bacterial pathogens
- virulence factors
- VFs
- microbe
- bacterial genome
- Bacteria/genetics/*pathogenicity
- Virulence Factors/*genetics
Literature & Tutorials:
PubMed Link: VFDB
2008 Update: VFDB 2008 release: an enhanced web-based resource for comparative pathogenomics
2008 Update: VFDB 2008 release: an enhanced web-based resource for comparative pathogenomics
This record last updated: 03-31-2008