iSPOT -- a web tool to infer the interaction specificity of families of protein modules
What you can do:
Infer the peptide binding specificity of any member of a family of protein binding domains.
Highlights:
- iSPOT is a web tool developed to infer the recognition specificity of protein module families;
- It is based on the SPOT procedure that utilizes information from position-specific contacts, derived from the available domain/ligand complexes of known structure, and experimental interaction data to build a database of residuex96residue contact frequencies.
- iSPOT is available to infer the interaction specificity of PDZ, SH3 and WW domains.
- For each family of protein domains, iSPOT evaluates the probability of interaction between a query domain of the specified families and an input protein/peptide sequence and makes it possible to search for potential binding partners of a given domain within the SWISS-PROT database.
- The experimentally derived interaction data utilized to build the PDZ, SH3 and WW databases of residuex96residue contact frequencies are also accessible.
Keywords:
- protein-protein interactions
- protein-protein interaction prediction tool
- domain-domain interactions
- protein domains
- domain/ligand complexes
- PDZ domain specificity
- SH3 domain specificity
- WW domain specificity
- residuex96residue contact frequencies
- peptide binding specificity prediction tool
- protein binding specificity prediction tool
- src Homology Domains
Literature & Tutorials:
This record last updated: 04-17-2014