SIFT -- predicting amino acid changes that affect protein function
What you can do:
Predict what amino acid substitutions will affect protein function.
Highlights:
- Single nucleotide polymorphism (SNP) studies and random mutagenesis projects identify amino acid substitutions in protein-coding regions.
- SIFT (Sorting Intolerant From Tolerant) is a program that predicts whether an amino acid substitution affects protein function so that users can prioritize substitutions for further study.
- It is shown that SIFT can distinguish between functionally neutral and deleterious amino acid changes in mutagenesis studies and on human polymorphisms.
Keywords:
- Single Nucleotide polymorphisms
- SNPs
- Single Nucleotide polymorphism analysis tool
- SNPs analysis tool
- Single Nucleotide polymorphism analysis tool
- SNPs analysis tool
- SNP mutation analysis tool
- protein function prediction tool
- amino acid substitution effect prediction tool
- human mutagenesis
- human genetic variations
- protein sequence alignment tool
Literature & Tutorials:
This record last updated: 06-17-2005