WebProAnalyst -- an interactive tool for analysis of quantitative structurex96activity relationships in protein families
What you can do:
Analyze quantitative structure-activity relationship of related protein families.
Highlights:
- This tool is designed for scanning quantitative structure-activity relationships in protein families.
- It allows users to search correlations between protein activity and physicochemical characteristics (i.e. hydrophobicity or alpha-helical amphipathicity) in queried sequences.
- It uses aligned amino acid sequences and data on protein activity (pK, K(m), ED(50), among others).
- WebProAnalyst implements methods of the known ProAnalyst package, including the multiple linear regression analysis and the sequence-activity correlation coefficient.
- In addition, WebProAnalyst incorporates a method based on neural networks.
- The WebProAnalyst reports a list of sites in protein family, the regression analysis parameters (including correlation values) for the relationships between the amino acid physicochemical characteristics in the site and the protein activity values.
- WebProAnalyst is useful in search of the amino acid residues that are important for protein function/activity.
- Furthermore, WebProAnalyst may be helpful in designing the protein-engineering experiments.
Keywords:
- protein active sites analysis tool
- protein functional sites analysis tool
- protein structure to function analysis tool
- protein physicochemical property analysis tool
- protein engineering tool
- protein Quantitative Structure-Activity Relationship
Literature & Tutorials:
This record last updated: 10-26-2006