ConSurf-DB -- evolutionary conservation profiles of protein structures database

What you can do:
Automatically calculate evolutionary conservation scores of key amino acid residues and map them on protein structures.
  • ConSurf-DB is a repository for evolutionary conservation analysis of the proteins of known structures in the Protein Data Bank (PDB).
  • Sequence homologues of each of the PDB entries were collected and aligned using standard methods.
  • The evolutionary conservation of each amino acid position in the alignment was calculated using the Rate4Site algorithm, implemented in the ConSurf web server.
  • The algorithm takes into account the phylogenetic relations between the aligned proteins and the stochastic nature of the evolutionary process explicitly.
  • Rate4Site assigns a conservation level for each position in the multiple sequence alignment using an empirical Bayesian inference.
  • Visual inspection of the conservation patterns on the 3D structure often enables the identification of key residues that comprise the functionally important regions of the protein.
  • protein sequence analysis tool
  • protein conserved sequences
  • protein functional sites
  • protein binding sites
  • protein catalytic sites
  • protein functional site mapping tool
  • protein evolution
This record last updated: 02-25-2009
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