The FoldX web server -- an online force field
What you can do:
Conduct rapid evaluation of the effect of mutations on the stability, folding and dynamics of proteins and nucleic acids.
Highlights:
- FOLD-X provides a fast and quantitative estimation of the importance of the interactions contributing to the stability of proteins and protein complexes.
- It calculates the folding pathways of proteins and the effect of a point mutation on the stability of a protein.
- The 2005 release allows the calculation of the stability of a protein, calculation of the positions of the protons and the prediction of water bridges, prediction of metal binding sites and the analysis of the free energy of complex formation.
- Alanine scanning, the systematic truncation of side chains to alanine, is also included.
- In addition, some reporting functions have been added, and it is now possible to print both the atomic interaction networks that constitute the protein, print the structural and energetic details of the interactions per atom or per residue, as well as generate a general quality report of the PDB structure.
Keywords:
- protein stability analysis tool
- protein folding analysis tool
- protein conformation
- protein mutations
- protein metal binding site prediction tool
- alanine scanning tool
- Single Nucleotide Polymorphism
- SNPs
Literature & Tutorials:
PubMed Link: The FoldX web server -- an online force field
This record last updated: 11-17-2005