HOLLYWOOD -- a comparative relational database of alternative splicing
What you can do:
Search for annotated information on alternative gene splicing.
Highlights:
- This database is an effort to integrate accurate exon and splice site annotation with current knowledge about splicing regulatory elements and predicted AS events, and to link information about the splicing of orthologous genes in different species.
- It was built upon genomic annotation of splicing patterns of known genes derived from spliced alignment of complementary DNAs (cDNAs) and expressed sequence tags, and links features such as splice site sequence and strength, exonic splicing enhancers and silencers, conserved and non-conserved patterns of splicing, and cDNA library information for inferred alternative exons. Hollywood was implemented as a relational database and currently contains comprehensive information for human and mouse.
- It is accompanied by a web query tool that allows searches for sets of exons with specific splicing characteristics or splicing regulatory element composition, or gives a graphical or sequence-level summary of splicing patterns for a specific gene.
- A streamlined graphical representation of gene splicing patterns is provided, and these patterns can alternatively be layered onto existing information in the UCSC Genome Browser.
Keywords:
- alternative splicing
- alternative splice events
- splice isoforms
- splicing signals
- splicing regulatory elements
- gene splicing analysis tool
- RNA splicing
- splicing patterns
- intron
- introns
- exon
- exonic splicing enhancers
- exonic splicing silencers
- splice sites
Literature & Tutorials:
This record last updated:
PubMed Link: HOLLYWOOD -- a comparative relational database of alternative splicing