EMAGE -- Edinburgh Mouse Atlas of Gene Expression

What you can do:
Search for in situ gene expression patterns in the developing mouse embryo.
Highlights:
  • EMAGE is a database of in situ gene expression patterns in the developing mouse embryo.
  • Domains of expression from raw data images are spatially integrated into a set of standard 3D virtual mouse embryos at different stages of development, allowing data interrogation by spatial methods.
  • Sites of expression are also described using an anatomy ontology and data can be queried using text-based methods.
  • Recent enhancements to EMAGE include advances in spatial search methods including: a refined local spatial similarity search algorithm, a method to allow global spatial comparison of patterns in EMAGE and subsequent hierarchical-clustering, and spatial searches across multiple stages of development.
  • Full 3D images of gene expression that have been generated using optical projection tomography (OPT) are included.
  • A completely re-designed website offers integration of many different search functions in HTML web pages, improved user feedback and the ability to find similar expression patterns at the click of a button; back-end refactoring from an object oriented to relational architecture, allowing associated SQL access; and the provision of further access by standard formatted URLs and a Java API.
  • Data coverage has been increased by sourcing from a greater selection of journals and developed automated methods for spatial data annotation that are being applied to spatially incorporate the genome-wide ( approximately 19 000 gene) 'EURExpress' dataset into EMAGE.
Keywords:
  • mouse embryos
  • mouse embryonic tissues
  • mouse embryo gene expression patterns
  • mouse tissue specific gene expression
  • anatomical gene expression mapping
This record last updated: 05-05-2010

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